Modeling intrinsic heterogeneity and growth of cancer cells
نویسندگان
چکیده
منابع مشابه
Modeling intrinsic heterogeneity and growth of cancer cells.
Intratumoral heterogeneity has been found to be a major cause of drug resistance. Cell-to-cell variation increases as a result of cancer-related alterations, which are acquired by stochastic events and further induced by environmental signals. However, most cellular mechanisms include natural fluctuations that are closely regulated, and thus lead to asynchronization of the cells, which causes i...
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ژورنال
عنوان ژورنال: Journal of Theoretical Biology
سال: 2015
ISSN: 0022-5193
DOI: 10.1016/j.jtbi.2014.11.017